A reverse osmosis system should be sanitized once each year. You may consider thoroughly sanitizing your Reverse Osmosis drinking water system while replacing your reverse osmosis water filters, which occurs every 6-12 months (depending on water conditions and system usage).
Your system can be sanitized with two to three tablespoons of unscented household bleach or non-bleach Sani-System sanitizer, which is proven to kill 99.99% of harmful bacteria.